Jessen, Henning J.Barbaras, DamienHamburger, MatthiasGademann, Karl2009-07-022009-07-022009-07-02200910.1021/ol901277qhttps://infoscience.epfl.ch/handle/20.500.14299/41022WOS:000268479900072An efficient synthesis of all four possible stereoisomers of the neurotrophic amide farinosone C was developed. The absolute and relative configuration was assigned by comparison of synthetic material with a derivatized authentic sample of the natural product. Several derivatives allowed for the generation of preliminary structure activity relationships concerning neurite outgrowth in PC-12 cells, unravelling l-tyrosinol-amide as the pharmacophore.Alzheimers-DiseasePaecilomyces-MilitarisCarboxylic-AcidsSynapse LossNeurodegenerationPyridoneMetabolitesAldehydesAlcoholsDeliverytext::journal::journal article::research article