Bartha, IstvanMclaren, Paul J.Brumme, ChansonHarrigan, RichardTelenti, AmalioFellay, Jacques2017-03-272017-03-272017-03-27201710.1371/journal.pcbi.1005339https://infoscience.epfl.ch/handle/20.500.14299/135917WOS:000395718800017We evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human genetic factors by using joint host/pathogen genetic data from 541 HIV infected individuals. We show that viral genetic diversity explains 29% of the variation in viral load while host factors explain 8.4%. Using a joint model including both host and viral effects, we estimate a total of 30% heritability, indicating that most of the host effects are reflected in viral sequence variation.text::journal::journal article::research article