Lima, TanesLi, Terytty YangMottis, AdrienneAuwerx, Johan2023-02-132023-02-132023-02-132022-03-0110.1038/s43587-022-00191-2https://infoscience.epfl.ch/handle/20.500.14299/194744WOS:000916575600010Aging is typified by a progressive decline in mitochondrial activity and stress resilience. Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and systemic homeostasis, which can comprise protective or detrimental responses during aging. We describe recent evidence arguing that defects in these conserved adaptive pathways contribute to aging and age-related diseases. Signaling pathways regulating the mitochondrial unfolded protein response, mitochondrial membrane dynamics, and mitophagy are discussed, emphasizing how their failure contributes to heteroplasmy and de-regulation of key metabolites. Our current understanding of how these processes are controlled and interconnected explains how mitochondria can widely impact fundamental aspects of aging.Cell BiologyGeriatrics & GerontologyNeurosciencesCell BiologyGeriatrics & GerontologyNeurosciences & Neurologyhuman skeletal-musclehigh-fat dietlife-spandna mutationsnicotinamide ribosideelectron-transportstress-responsequality-controlmouse modelcomplex-iitext::journal::journal article::review article