Islas-Gonzalez, GabrielaZhu, Jieping2010-11-252010-11-252010-11-25200010.1055/s-2000-6519https://infoscience.epfl.ch/handle/20.500.14299/58518Salt effects exerted on the cycloetherification of linear diarylheptanoid 3-OH-4-MeOC6H3(CH2)2COCMe2CO(CH2)2C6H3-3-F-4-NO2 were investigated. Both salting-in and salting-out alkali salts were found to inhibit the macrocyclization. Ion-pairing exchange was proposed to account for the exptl. observations. [on SciFinder (R)]Substitution reaction (arom.; inhibitory salt effect on the SNAr-based macrocycloetherification of a linear diarylheptanoid); Etherification (cyclo-; inhibitory salt effect on the SNAr-based macrocycloetherification of a linear diarylheptanoid); Cation exchange; Ion pairs; Macrocyclization; Salt effect; Solvent polarity effect (inhibitory salt effect on the SNAr-based macrocycloetherification of a linear diarylheptanoid); Alkali metal salts Role: CAT (Catalyst use)USES (Uses) (inhibitory salt effect on the SNAr-based macrocycloetherification of a linear diarylheptanoid)salt effect macrocyclization cycloetherification nucleophilic arom substitutiontext::journal::journal article::research article