Auwerx, JohanYamamoto, HiroyasuMouchiroud, Laurent2015-09-222015-09-222015-09-222012https://infoscience.epfl.ch/handle/20.500.14299/118378The present invention provides methods of increasing muscle mass and muscle miochodrial oxidative metabolism. Additionally, the invention provides treating various disorders associated with mitochondrial dysfunction, including but not limited to metabolic disorders, muscular dystrophy disorders, neurodegenerative diseases, chronic inflammatory diseases, and diseases of aging.patentUS2014147434WO201215319146545820