Immunoisolation of adult porcine islets for the treatment of diabetes mellitus. The use of photopolymerizable polyethylene glycol in the conformal coating of mass-isolated porcine islets

Hill, R. S.Cruise, G. M.Hager, S. R.Lamberti, F. V.Yu, X.Garufis, C. L.Yu, Y.Mundwiler, K. E.Cole, J. F.Hubbell, J. A.Hegre, O. D.Scharp, D. W.2006-02-272006-02-272006-02-27199710.1111/j.1749-6632.1997.tb52208.xhttps://infoscience.epfl.ch/handle/20.500.14299/226510Functional porcine islets, free of known pathogens, can serve as a source of insulin producing cells for the treatment of experimentally induced insulin dependent Diabetes Mellitus. Porcine islets can be conformally coated (microencapsulated) with a covalently linked, stable permselective membrane while maintaining islet viability and function. The PEG conformal coating is immunoprotective in a discordant xenograft animal model (porcine islets to rat). [on SciFinder (R)]Immunoisolation of adult porcine islets for the treatment of diabetes mellitus. The use of photopolymerizable polyethylene glycol in the conformal coating of mass-isolated porcine isletstext::journal::journal article::research article