Synthesis of branched seven-membered 1-N-iminosugars and their evaluation as glycosidase inhibitors

Li, HongqingZhang, YongminFavre, SylvainVogel, PierreSollogoub, MatthieuBleriot, Yves2012-07-132012-07-132012-07-13201210.1016/j.carres.2011.10.039https://infoscience.epfl.ch/handle/20.500.14299/83851WOS:000305338000011Four branched tetra- and pentahydroxylated azepanes have been synthesized from a common azepane precursor through dihydroxylation followed by deoxygenation. They have been assayed as glycosidase inhibitors on a panel of 22 glycosidases and one methylated azepane displayed selective, competitive, and moderate inhibition toward bovine kidney alpha-L-fucosidase. (C) 2011 Elsevier Ltd. All rights reserved.IminosugarGlycosidaseInhibitorAzepaneType-2 Diabetes-MellitusAlpha-GlucosidasePolyhydroxy PiperidinesSelective InhibitorsFacile SynthesisIsofagominePotentAgentsCationRingSynthesis of branched seven-membered 1-N-iminosugars and their evaluation as glycosidase inhibitorstext::journal::journal article::research article