Synthesis and Reactivity of Iron Acyl Complexes Modeling the Active Site of [Fe]-Hydrogenase

Chen, DafaScopelliti, RosarioHu, Xile2009-12-282009-12-282009-12-28201010.1021/ja9100485https://infoscience.epfl.ch/handle/20.500.14299/45017WOS:000275084700013A [FeIIFeII] dithiolate complex containing acyl and carbonyl ligands was synthesized. The diiron complex reacted with phosphine, cyanide, isocyanide, and CO to give monomeric FeII complexes reproducing the first coordination sphere of the active site of [Fe]-hydrogenase (H2-forming methylene-tetrahydromethanopterin dehydrogenase, Hmd) in various states. All the acyl and carbonyl carbons in the diiron complex underwent facile isotopic exchange with 13CO via monomeric Fe tricarbonyl intermediates.Cluster-Free HydrogenaseCrystal-StructureCarbon-MonoxideMethanogenic ArchaeaLight-InactivationH-2 ActivationHmdFeInsertionCoSynthesis and Reactivity of Iron Acyl Complexes Modeling the Active Site of [Fe]-Hydrogenasetext::journal::journal article::research article