Pseudo-prolines (Psi Pro): direct insertion of Psi Pro systems into cysteine containing peptides

Guichou, JFPatiny, LMutter, M2006-02-092006-02-092006-02-09200210.1016/S0040-4039(02)00755-4https://infoscience.epfl.ch/handle/20.500.14299/222291WOS:000176019700022149The direct conversion of cysteine (Cys) containing peptides into conformationally constrained pseudo-proline (TPro) derivatives by intraresidual N,S-acetalisation has been achieved. This post-synthetic modification represents a versatile tool in structure-activity studies of bioactive peptides as exemplified for the immunosuppressive cyclosporine A (CsA) analogue [D-Cys]*CsA. (C) 2002 Elsevier Science Ltd. All rights reserved.Pseudo-prolines (Psi Pro): direct insertion of Psi Pro systems into cysteine containing peptidestext::journal::journal article::research article