Schlosser, Manfred2012-07-042012-07-042012-07-04200710.1055/s-2007-992384https://infoscience.epfl.ch/handle/20.500.14299/83372WOS:000253628300002Halogens, in particular fluorine atoms, are favorite tools to fine-tune the chemical and biological properties of pharmaceutical or agricultural development products. At the same time, such an electronegative substituent can effectively assist the site-selective functionalization of an aromatic or heterocyclic core compound by directing a metal to the targeted position, the metal acting as a harbinger for the definitive substituent. The concept is illustrated by typical examples selected from the carbazole, indole, pyrrole, pyrazole, imidazole, pyridine, quinoline and pyrimidine fields.fluorinefunctionalizationhalogensorganometallic reagentsorganic synthesisregioselectivityRegiochemically Exhaustive FunctionalizationRegioselective Ortho-LithiationSelective FunctionalizationRegioexhaustive Functionalization3-Substituted PyrrolesConvenient SynthesisDirected LithiationNormal-ButyllithiumExchange-ReactionsProtecting Grouptext::journal::journal article::research article