Bao, XuWang, QianZhu, Jieping2019-08-312019-08-312019-08-312019-08-1310.1002/chem.201902918https://infoscience.epfl.ch/handle/20.500.14299/160733WOS:000481094000001The reaction of readily available and bench-stable N-alkoxypyridinium salts with arylboronic and vinylboronic acids afforded delta-aryl and delta-vinyl alcohols, respectively, in the presence of fac-Ir(ppy)(3) and Cu(OTf)(2) dual catalysts. The reaction takes place through a domino process involving the reductive generation of alkoxyl radicals, 1,5-hydrogen atom transfer (1,5-HAT) and the copper-catalyzed cross-coupling reaction of the resulting translocated carbon radicals with boronic acids. Complementary to the Minisci reaction, this method allows for the arylation of nucleophilic alkyl radicals with both electron-rich and electron-poor arenes under mild reaction conditions.Chemistry, MultidisciplinaryChemistryalkoxyl radicalc-h activationcross-couplingdual catalysisphotoredox catalystc-h bondsphotoredox catalysisrelay cyclizationsnitrogen-radicalsallylic alcoholsalkoxyl radicalshydrogen-atomcopperalkenesfunctionalizationtext::journal::journal article::research article