Fayol, AudeZhu, Jieping2010-11-252010-11-252010-11-25200210.1002/1521-3773(20021004)41:19<3633::AID-ANIE3633>3.0.CO;2-Thttps://infoscience.epfl.ch/handle/20.500.14299/58504Five bonds form in one pot, from three well-designed yet readily accessible substrates. Simply mixing an o-alkynyl aniline, e.g., 2-H2NC6H4C==CCO2Me, an aldehyde, e.g., heptanal, and ammonium chloride in toluene at room temp., followed by addn. of an isocyanoacetamide, e.g., PhCH2CH(CN)COR (R = morpholino), and heating to reflux, provides the polysubstituted furo[2,3-c]quinoline, e.g. I (same R), in good to excellent yield. [on SciFinder (R)]Amines Role: RCT (Reactant)RACT (Reactant or reagent) (arom.alkynyl; multicomponent synthesis of furo[23-c]quinolines from alkynyl anilinesaldehydesand isocyanoacetamides); Aldehydes; Isocyanides Role: RCT (Reactant)RACT (Reactant or reagent) (multicomponent synthesis of furo[23-c]quinolines from alkynyl anilinesaldehydesand isocyanoacetamides)furoquinoline multicomponent synthesistext::journal::journal article::research article