Pircher, H.Groscurth, P.Baumhutter, S.Aguet, M.Zinkernagel, R. M.Hengartner, H.2007-12-122007-12-122007-12-12198610.1002/eji.1830160212https://infoscience.epfl.ch/handle/20.500.14299/15392A murine monoclonal antibody (I-17, IgM) has the following functional effects on murine long-term T cell clones: inhibition of cell-mediated lysis, induction of proliferation, release of lymphokines and change of the cell morphology. The determinant detected by I-17 is expressed on long-term T lines but not on thymocytes, lymph node cells and spleen cells. I-17 precipitated proteins with apparent molecular mass of 220 kDa, 170 kDa, 150 kDa and 100 kDa. Biochemical studies indicate that the determinant recognized by I-17 is tunicamycin sensitive and that I-17 binds to the alpha chain of the lymphocyte function-associated antigen (LFA-1).text::journal::journal article::research article