From Alkyl Halides to Ketones: Nickel-Catalyzed Reductive Carbonylation Utilizing Ethyl Chloroformate as the Carbonyl Source

Shi, RenyiHu, Xile2019-08-012019-08-012019-08-012019-05-2710.1002/anie.201903330https://infoscience.epfl.ch/handle/20.500.14299/159476WOS:000474803100049Ketones are an important class of molecules in synthetic and medicinal chemistry. Rapid and modular synthesis of ketones remains in high demand. Described here is a nickel-catalyzed three-component reductive carbonylation method for the synthesis of dialkyl ketones. A wide range of both symmetric and asymmetric dialkyl ketones can be accessed from alkyl halides and a safe CO source, ethyl chloroformate. The approach offers complementary substrate scope to existing carbonylation methods while avoiding the use of either toxic CO or metal carbonyl reagents.Chemistry, MultidisciplinaryChemistryalkyl halidescarbonylationketonesnickelsynthetic methodscross-coupling reactionsacid-chloridesreagentsiminesestersFrom Alkyl Halides to Ketones: Nickel-Catalyzed Reductive Carbonylation Utilizing Ethyl Chloroformate as the Carbonyl Sourcetext::journal::journal article::research article