Grosheva, DariaCramer, Nicolai2018-12-132018-12-132018-12-132018-10-0810.1002/anie.201809173https://infoscience.epfl.ch/handle/20.500.14299/152877WOS:000446306600049A catalytic enantioselective method for the synthesis of chiral 1H-isoindoles bearing quaternary stereogenic centers is reported. Powered by readily accessible phosphordiamidite ligands, the presented palladium(0)-catalyzed C-H function-alization uses trifluoroacetimidoyl chlorides as electrophilic components. It delivers previously inaccessible perfluoroalky-lated 1H-isoindoles in high yields and enantioselectivities. The subsequent diastereoselective addition of nucleophiles provides access to densely substituted and sterically hindered isoindolines.Chemistry, MultidisciplinaryChemistryasymmetric catalysisc-h activationfluorineheterocyclespalladiumasymmetric-synthesistrifluoroacetimidoyl chloridesbond functionalizationmedicinal chemistryfacile synthesis3+2 annulationgamma-lactamsbeta-lactamsarylationactivationEnantioselective Access to 1H-Isoindoles with Quaternary Stereogenic Centers by Palladium(0)-Catalyzed C-H Functionalizationtext::journal::journal article::research article