Brand, Jonathan P.Waser, Jerome2012-03-222012-03-222012-03-22201210.1021/ol203289vhttps://infoscience.epfl.ch/handle/20.500.14299/78944WOS:000300458200020A method for the para-selective alkynylation of anilines is reported using AuCl as catalyst and triisopropylsilylethynyl-1,2-benziodoxol-3(1H)-one (TIPS-EBX) as an electrophilic acetylene equivalent. Para-alkynyl anilines substituted at positions 2 or 3 were obtained in one step from simple anilines under mild conditions (room temperature to 60 degrees C) under air. The methodology could also be extended to the alkynylation of trimethoxybenzenes.C-H Bond FunctionalizationDirect AlkynylationEthynylationAlkynesArenesGoldFunctionalizationCatalysistext::journal::journal article::research article