He, Yu‐PingQuan, RuiLi, Xing‐ZiZhu, JiepingWu, Hua2023-04-182023-04-182023-04-182023-04-2410.1002/anie.202217954https://infoscience.epfl.ch/handle/20.500.14299/196998WOS:000956183100001An unprecedent asymmetric catalytic benzilic amide rearrangement for the synthesis of α,α-disubstituted piperazinones is reported. The reaction proceeds via a domino [4+1] imidazolidination/formal 1,2-nitro- gen shift/1,2-aryl or alkyl migration sequence, employing readily available vicinal tricarbonyl compounds and 1,2- diamines as starting materials. This approach provides an efficient access to chiral C3-disubsituted piperazin-2-ones with high enantiocontrol, which are exceedingly difficult to access from the existing synthetic method- ologies. The observed enantioselectivity was proposed to be controlled by dynamic kinetic resolution in the 1,2- aryl/alkyl migration step. The resulting densely function- alized products are versatile building blocks to bioactive natural products, drug molecules and their analogues.Benzilic Amide RearrangementDynamic Kinetic ResolutionOrganocatalysisPiperazinoneα-Tertiary Aminetext::journal::journal article::research article