Larghi, Enrique L.Obrist, Blaise V.Kaufman, Teodoro S.2010-11-302010-11-302010-11-30200810.1016/j.tet.2008.03.036https://infoscience.epfl.ch/handle/20.500.14299/61366WOS:000256179700046A new strategy for the synthesis of benzo[de][1,6]naphthyridine derivative 2,3,3a,4,5,6-hexahydroaaptamine, which involves the construction of the isoquinoline ring after elaboration of the quinoline moiety, is described. Since 2,3,3a,4,5,6-hexahydroaaptamine has been previously synthesized as a key intermediate en route to the marine alkaloid aaptamine, access to this compound represents a formal total synthesis of the natural product. (c) 2008 Elsevier Ltd. All rights reserved.formal total synthesisaaptaminebenzo[de][1,6]naphthyridine alkaloids2,3,3a,4,5,6-hexahydroaaptamineSponge Aaptos-AaptosModified Curtius ReactionNatural-ProductsAntineoplastic AgentsConvenient ReagentLactarius-NecatorIsoaaptamineChemistryStephaoxocanesIdentificationA formal total synthesis of the marine alkaloid aaptaminetext::journal::journal article::research article