Ghoreishizadeh, SaraGeorgiu, PantelisCarrara, SandroDe Micheli, Giovanni2016-06-142016-06-142016-06-14201610.1109/ISCAS.2016.7539193https://infoscience.epfl.ch/handle/20.500.14299/126625WOS:000390094703001A fully-integrated differential biosensing platform on CMOS is presented for miniaturized enzyme-based electrochemical sensing. It enables sensor background current elimination and consists of a differential sensor array and a <i>differential readout IC</i> (DiRIC). The sensor array includes a four-electrode sensor for amperometric electrochemical sensing, as well as a differential ISFET-based pH sensor to calibrate the biosensors. The ISFET is biased in weak inversion and co-designed with DiRIC to enable pH measurements from 1 to 14 with resolution of 0.1 pH. DiRIC enables differential current measurement in the range of ±100 μA with more than 120dB dynamic range.sensor arrayISFETdifferential readouttext::conference output::conference proceedings::conference paper