Wong, Ting YatRadua, JoaquimPomarol-Clotet, EdithSalvador, RaymondAlbajes-Eizagirre, AntonSolanes, AleixCanales-Rodriguez, Erick J.Guerrero-Pedraza, AmaliaSarro, SalvadorKircher, TiloNenadic, IgorKrug, AxelGrotegerd, DominikDannlowski, UdoBorgwardt, StefanRiecher-Roessler, AnitaSchmidt, AndreAndreou, ChristinaHuber, Christian G.Turner, JessicaCalhoun, VinceJiang, WenhaoClark, SarahWalton, EstherSpalletta, GianfrancoBanaj, NerisaPiras, FabrizioCiullo, ValentinaVecchio, DanielaLebedeva, IrinaTomyshev, Alexander S.Kaleda, VasilyKlushnik, TatyanaFilho, Geraldo BusattoZanetti, Marcus ViniciusSerpa, Mauricio HenriquesPenteado Rosa, Pedro GomesHashimoto, RyotaFukunaga, MasakiRichter, AnjaKraemer, BerndGruber, OliverVoineskos, Aristotle N.Dickie, Erin W.Tomecek, DavidSkoch, AntoninSpaniel, FilipHoschl, CyrilBertolino, AlessandroBonvino, AuroraDi Giorgio, AnnabellaHolleran, LaurenaCiufolini, SimoneMarques, Tiago ReisDazzan, PaolaMurray, RobinLamsma, JelleCahn, Wiepkevan Haren, NeeltjeDiaz-Zuluaga, Ana M.Pineda-Zapata, Julian A.Vargas, CristianLopez-Jaramillo, Carlosvan Erp, Theo G. M.Gur, Ruben C.Nickl-Jockschat, Thomas2020-10-152020-10-152020-10-152020-09-0110.1017/S0033291719002149https://infoscience.epfl.ch/handle/20.500.14299/172502WOS:000573873900010Background Positive symptoms are a useful predictor of aggression in schizophrenia. Although a similar pattern of abnormal brain structures related to both positive symptoms and aggression has been reported, this observation has not yet been confirmed in a single sample. Method To study the association between positive symptoms and aggression in schizophrenia on a neurobiological level, a prospective meta-analytic approach was employed to analyze harmonized structural neuroimaging data from 10 research centers worldwide. We analyzed brain MRI scans from 902 individuals with a primary diagnosis of schizophrenia and 952 healthy controls. Results The result identified a widespread cortical thickness reduction in schizophrenia compared to their controls. Two separate meta-regression analyses revealed that a common pattern of reduced cortical gray matter thickness within the left lateral temporal lobe and right midcingulate cortex was significantly associated with both positive symptoms and aggression. Conclusion These findings suggested that positive symptoms such as formal thought disorder and auditory misperception, combined with cognitive impairments reflecting difficulties in deploying an adaptive control toward perceived threats, could escalate the likelihood of aggression in schizophrenia.Psychology, ClinicalPsychiatryPsychologyaggressioncerebral cortical thinninghostilityimpulse controlpositive symptomsprospective meta-analysisschizophreniamatter volume abnormalitiesnegative-syndrome-scaleauditory hallucinationsmidcingulate cortexreactive aggressionpsychotic symptomsmental-disorderscingulate cortexneural circuitryviolencetext::journal::journal article::research article