An efficient chloro-deamination procedure, application to the synthesis of advanced vancomycin C-O-D-O-E ring

Vergne, CarolineBois-Choussy, MicheleZhu, Jieping2010-11-252010-11-252010-11-25199810.1055/s-1998-1857https://infoscience.epfl.ch/handle/20.500.14299/58535An efficient chloro-deamination procedure was developed and a remarkable deuterium isotope effect indicating a radical mechanism was documented. Key to success was the coexistence of a reductant (CuCl) and a ligand-transfer agent (CuCl2) in the reaction medium employing CD3CN as co-solvent of CCl4. The procedure was applied to the synthesis of advanced vancomycin models. [on SciFinder (R)]Deamination (chloro-; synthesis of advanced vancomycin C-O-D-O-E ring via chloro-deamination)vancomycin fragment synthesis chlorodeamination; deamination chloro vancomycin fragment synthesisAn efficient chloro-deamination procedure, application to the synthesis of advanced vancomycin C-O-D-O-E ringtext::journal::journal article::research article