Fischi Gomez, EldaBonnier, GuillaumeFalkowskiy, PavelRomascano, David Paul RogerSchluep, MyriamDu Pasquier, RenaudDaducci, AlessandroThiran, Jean-PhilippeKruger, GunnarGranziera, Cristina2017-06-222017-06-222017-06-222017https://infoscience.epfl.ch/handle/20.500.14299/138576We explored the sensitivity of a novel diffusion MRI method i.e. “Neurite orientation dispersion and density imaging”, to detect and characterize brain microstructure alterations in relapsing-remitting multiple sclerosis patients that we followed up over 2 years. Cross-sectionally, NODDI revealed that an increase in orientation dispersion and a decrease in neurite density in NAWM and in lesions of RRMS patients compared to healthy subjects. Longitudinally, NODDI measured a decreased dispersion and an increased neurite density in MS lesions at 2 years follow-up. Also, NODDI metrics at baseline were highly related to cognition at both baseline and follow-up.text::conference output::conference paper not in proceedings