Pd-Catalyzed Dehydrogenative Aryl−Aryl Bond Formation via Double C(sp2)−H Bond Activation: Efficient Synthesis of [3,4]-Fused Oxindoles

Bunescu, AlaPiou, TiffanyWang, QianZhu, Jieping2015-01-172015-01-172015-01-17201510.1021/ol503442nhttps://infoscience.epfl.ch/handle/20.500.14299/110359WOS:000348331800042A Pd(0)-catalyzed double cyclization of easily available o-bromoanilides leading to strained [3,4]-fused oxindoles was developed. The reaction proceeded through a highly ordered sequence involving key carbopalladation, 1,4-Pd migration, and C(sp2)−H functionalization steps.Pd-Catalyzed Dehydrogenative Aryl−Aryl Bond Formation via Double C(sp2)−H Bond Activation: Efficient Synthesis of [3,4]-Fused Oxindolestext::journal::journal article::research article