Bunin, Gene A.Lima, Fernando V.Georgakis, ChristosHunt, Christopher M.2009-10-022009-10-022009-10-02201010.1080/00986440903288096https://infoscience.epfl.ch/handle/20.500.14299/43074A stirred-tank reactor was built with the objective of rapid and accurate temperature control in the reaction vessel. A first-principles heat transfer model was developed for the jacketed batch system, with the jacket inlet temperature used to control the vessel temperature. A model predictive controller was implemented to follow a rapidly changing temperature profile that cycled between steep heating and cooling motifs, and was tested experimentally at progressively shorter temperature cycles. For a water-solvent-water-jacket system, a cycle consisting of increasing and decreasing the temperature by 15°C over a period of 20 minutes was achieved in practice. The performance of the MPC controller was explained by calculating the dynamic operability characteristics of the process.model predictive controldynamic operabilitycontrol of crystal morphologytemperature cyclingtext::journal::journal article::research article