Poganik, Jesse R.Aye, Yimon2018-12-132018-12-132018-12-132018-11-1510.1016/j.chembiol.2018.10.027https://infoscience.epfl.ch/handle/20.500.14299/151961WOS:000450370800002Challenging the paradigm of SECIS-dependent selenoprotein translation, in this issue of Cell Chemical Biology Guo et al. (2018) introduce a new selenoprotein profiling platform with which they identify novel selenoproteins apparently lacking SECIS. With increased interest in covalent targeting of reactive Sec residues in drug discovery, their method adds a valuable contribution toward expanding the druggable human proteome.Biochemistry & Molecular Biologyselenoproteinstext::journal::journal article::research article