Wozniak, LukaszTan, Jin-FayQui-Hien NguyenMadron du Vigné, AdrienSmal, VitaliiCao, Yi-XuanCramer, Nicolai2020-10-222020-10-222020-10-222020-09-2310.1021/acs.chemrev.0c00559https://infoscience.epfl.ch/handle/20.500.14299/172666WOS:000575686700010The development of catalytic enantioselective transformations, enabling the construction of complex molecular scaffolds from simple precursors, has been a long-standing challenge in organic synthesis. Recent achievements in transition-metal catalyzed enantioselective functionalizations of carbon-hydrogen (C-H) bonds represent a promising pathway toward this goal. Over the last two decades, iridium catalysis has evolved as a valuable tool enabling the stereocontrolled synthesis of chiral molecules via C-H activation. The development of iridium-based systems with various chiral ligand classes, as well as studies of their reaction mechanisms, has resulted in dynamic progress in this area. This review aims to present a comprehensive picture of the enantioselective functionalizations of C-H bonds by chiral iridium complexes with emphasis on the mechanisms of the C-H activation step.Chemistry, MultidisciplinaryChemistryasymmetric intermolecular hydroarylationvinyl ethersgamma-lactamsselective hydroarylationsaturated-hydrocarbonsc(sp(3))-h borylationconjugate additionoxidative additionmetal-complexes3+2 annulationtext::journal::journal article::review article