Pianowski, ZbigniewGorska, KatarzynaOswald, LaurenceMerten, ChristophWinssinger, Nicolas2020-02-282020-02-282020-02-282009-04-2010.1021/ja809656khttps://infoscience.epfl.ch/handle/20.500.14299/166545Nucleic acid-templated reactions leading to a fluorescent product represent an attractive strategy for the detection and imaging of cellular nucleic acids. Herein we report the use of a Staudinger reaction to promote the reduction of profluorescent azidorhodamine. The use of two cell-permeable GPNA probes, one labeled with the profluorescent azidorhodamine and the other with trialkylphosphine, enabled the detection of the mRNA encoding O-6-methylguanine-DNA methyltransferase in intact cells.text::journal::journal article::research article