Rossolini, ThomasDas, AshisNicolai, StefanoWaser, Jerome2022-08-012022-08-012022-08-012022-07-1110.1021/acs.orglett.2c01838https://infoscience.epfl.ch/handle/20.500.14299/189529WOS:000829240700001A Pd-catalyzed method based on the use of a molecular tether is described for olefin difunctionalization. Enabled by an easily introduced trifluoroacetaldehyde-derived tether, a simultaneous introduction of oxygen and nitrogen heteroatoms across unsaturated carbon-carbon bonds was achieved under oxidative conditions, most probably via high-valent Pd inter-mediates. Good yields and high diastereoselectivity were obtained with aryl-substituted alkenes, whereas nonterminal alkyl-substituted olefins gave aza-Heck products. Tether cleavage under mild conditions fast access to functionalized alcohols.Chemistry, OrganicChemistrycatalyzed intermolecular aminoacetoxylationhydrogen-peroxideiodonium saltsalcoholsaminocarbonylationfunctionalizationaminopalladationaminestext::journal::journal article::research article