New synthetic route toward polyketide-like macrolides

Coste, GéraldGerber-Lemaire, Sandrine2006-02-162006-02-162006-02-16200610.1055/s-2006-932495https://infoscience.epfl.ch/handle/20.500.14299/224107WOS:0002362536000048305New pathways toward the synthesis of polyketide-like macrolides have been developed through the functionalization of long chain polyolic fragments readily obtained from 3,3'-methylenebis{[6-(benzyloxy)methoxy]cyclohept-3-en-1-ol} derivatives 6. This synthetic route generates a large variety of stereoisomers and thus can be applied to the preparation of a library of polyhydroxylated macrocycles, analogues of natural bioactive macrolides.long chain polyolsmacrolactonizationolefinationpolyketide macrolidesring-closing metathesis.New synthetic route toward polyketide-like macrolidestext::journal::journal article::research article