Bonazzi, SimoneGüttinger, StephanZemp, IvoKutay, UlrikeGademann, Karl2007-09-022007-09-02200710.1002/anie.200703134https://infoscience.epfl.ch/handle/20.500.14299/11626WOS:00025122880004211380Immunofluorescence assays indicate that anguinomycin C is a potent inhibitor of protein export from the nucleus. Key features in the total synthesis of this antitumor natural product include a Cr-catalyzed enantioselective hetero-Diels– Alder reaction, a Negishi reaction with stereoinversion, and application of the DIOZ auxiliary.antitumor agentsleptomycinsnuclear exportpolyketidestotal synthesistext::journal::journal article::research article