Cristau, PierreMartin, Marie-ThereseDau, Marie-Elise Tran HuuVors, Jean-PierreZhu, Jieping2010-11-252010-11-252010-11-25200410.1021/ol0488439https://infoscience.epfl.ch/handle/20.500.14299/58483Three tetrapeptides incorporating a 14-membered (Ri+1, Si+2) cycloisodityrosine at the i + 1 and i + 2 positions were designed and synthesized. Conformational anal. by 1H NMR and CD spectra as well as mol. modeling indicated that they all adopt a beta -turn conformation. While the CD spectrum of peptide I is characteristic of the typical type-II beta -turn (max. at .apprx.200 nm and a min. at .apprx.220 nm), that of peptide II (atropisomer of I) is opposite in sign to the expected spectrum of the type-II beta -turn. [on SciFinder (R)]Atropisomers; Conformation; beta -Turn (prepn. and conformation anal. of cycloisodityrosine-based tetrapeptides as strained cyclophane-induced beta -turn templates); Cyclophanes Role: PRP (Properties)SPN (Synthetic preparation)PREP (Preparation) (prepn. and conformation anal. of cycloisodityrosine-based tetrapeptides as strained cyclophane-induced beta -turn templates); Peptides Role: PRP (Properties)SPN (Synthetic preparation)PREP (Preparation) (tetrapeptides; prepn. and conformation anal. of cycloisodityrosine-based tetrapeptides as strained cyclophane-induced beta -turn templates); beta -Turn (type II; prepn. and conformation anal. of cycloisodityrosine-based tetrapeptides as strained cyclophane-induced beta -turn templates)cycloisodityrosine tetrapeptide strained cyclophane beta turn prepn conformationtext::journal::journal article::research article