Pd(II)-catalyzed intramolecular aminopalladation/direct C–H arylation under aerobic conditions: synthesis of pyrrolo[1,2-a]indoles

Piou, TiffanyNeuville, LucZhu, Jieping2013-05-012013-05-012013-05-01201310.1016/j.tet.2013.01.003https://infoscience.epfl.ch/handle/20.500.14299/91899WOS:000318457900009Heating a DMA/pivalic acid (v/v = 4/1) solution of diversely substituted 6-(phenylamino)hex-2-ynoates in the presence of a catalytic amount of Pd(OAc)2 under oxygen atmosphere afforded pyrrolo[1,2-a]indoles in moderate to good yields. A domino sequence involving intramolecular aminopalladation followed by C-H activation and reductive elimination was proposed to account for the observed bis-cyclization.Palladium catalysisDomino reactionCeH activationIndoleAminopalladationPd(II)-catalyzed intramolecular aminopalladation/direct C–H arylation under aerobic conditions: synthesis of pyrrolo[1,2-a]indolestext::journal::journal article::research article