Pedroni, JuliaCramer, Nicolai2016-07-192016-07-192016-07-19201610.1021/acs.orglett.6b00795https://infoscience.epfl.ch/handle/20.500.14299/127248WOS:000374436800056Perfluoroalkylated indoles are valuable compounds in drug discovery. A Pd(0)-catalyzed C(sp(3))-H functionalization enables access to 2-(trifluoromethyl)indoles from trifluoroacetimidoyl chlorides. These are stable compounds, easily obtained from anilines. The cyclization operates with catalyst loadings as low as 1 mol % and accommodates a variety of substituents.text::journal::journal article::research article