Boer, G.Johann, R.Rohner, J.Merenda, F.Delacretaz, G.Renaud, P.Salathé, R. P.2012-06-202012-06-202012-06-20200710.1063/1.2804768https://infoscience.epfl.ch/handle/20.500.14299/81983WOS:000251325900054An array of four independent laser traps is combined with a polydimethylsiloxane microfluidic chip to form a very compact system allowing parallel processing of biological objects. Strong three dimensional trapping allows holding objects such as functionalized beads in flows at speeds near 1 mm/s, enabling rapid processing. By pressure control of the inlet flows, the trapped objects can be put in contact with different solutions for analysis purpose. This setup, including a fluorescence excitation-detection scheme, offers the potential to perform complex biochemical manipulations on an ensemble of microparticles. (c) 2007 American Institute of Physics.TweezersSystemsDevicesForcesCells[LAT]biochemistrybiological techniquesbioMEMScellular biophysicsfluorescencelab-on-a-chipmicrofluidicsmolecular biophysicsradiation pressuretext::journal::journal article::research article