Pirenne, VincentRobert, Emma G. L.Waser, Jerome2021-06-052021-06-052021-06-052021-05-0510.1039/d1sc01127hhttps://infoscience.epfl.ch/handle/20.500.14299/178487WOS:000654359200001The efficient catalytic activation of donor-acceptor aminocyclopropanes lacking the commonly used diester acceptor is reported here in a (3 + 2) dearomative annulation with indoles. Bench-stable tosyl-protected aminocyclopropyl esters were converted into cycloadducts in 46-95% yields and up to 95 : 5 diastereomeric ratio using catalytic amounts of triethylsilyl triflimide. Tricyclic indoline frameworks containing four stereogenic centers including all-carbon quaternary centers were obtained.Chemistry, MultidisciplinaryChemistryenol silyl ethershighly diastereoselective synthesisring-opening-cyclizationenantioselective synthesisasymmetric cyclopropanationactivated cyclopropanescycloadditionaldehydesconstructionderivativestext::journal::journal article::research article