Synthesis of ring-A-substituted tryptophan by a palladium-catalyzed heteroannulation reaction

Jia, YanxingZhu, Jieping2010-11-252010-11-252010-11-25200510.1055/s-2005-917079https://infoscience.epfl.ch/handle/20.500.14299/58465Coupling of substituted 2-iodoanilines with Me (S)-2-[di(tert-butoxycarbonyl)amino]-5-oxopentanoate, derived from glutamic acid, in DMF in the presence of Pd(OAc)2 and DABCO provides substituted tryptophans in good to excellent yields. [on SciFinder (R)]Arylation (Heckintramol.; prepn. of ring-A-substituted tryptophan by palladium-catalyzed heteroannulation); Amino acids Role: SPN (Synthetic preparation)PREP (Preparation) (arom.; prepn. of ring-A-substituted tryptophan by palladium-catalyzed heteroannulation); Heterocyclization (prepn. of ring-A-substituted tryptophan by palladium-catalyzed heteroannulation)tryptophan prepn; iodoaniline aminooxopentanoate palladium catalyzed heteroannulation intramol HeckSynthesis of ring-A-substituted tryptophan by a palladium-catalyzed heteroannulation reactiontext::journal::journal article::research article