Bastings, Maartje M. C.2023-02-272023-02-272023-02-272023-01-3110.1002/anie.202218334https://infoscience.epfl.ch/handle/20.500.14299/195089WOS:000922359500001The elegant geometry of viruses has inspired bio-engineers to synthetically explore the self-assembly of polyhedral capsids employed to protect new cargo or change an enzymatic microenvironment. Recently, Yang and co-workers used DNA nanotechnology to revisit the icosahedral capsid structure of the phiX174 bacteriophage and reloaded the original viral genome as cargo into their fully synthetic architecture. Surprisingly, when using a favorable combination of structural rigidity and dynamic multivalent cargo entrapment, the synthetic particles were able to infect non-competent bacterial cells and produce the original phiX174 bacteriophage. This work presents an exciting new direction of DNA nanotech for bio-engineering applications which involve bacterial interactions.Chemistry, MultidisciplinaryChemistrybacterial infectionbiotechnologydna origamistructural rigidityvirus-inspired particlestext::journal::journal article::research article