Kinetics of photoinduced RNA refolding by real-time NMR spectroscopy

Wenter, PhilippFuertig, BorisHainard, AlexandreSchwalbe, HaraldPitsch, Stefan2006-02-272006-02-272006-02-27200510.1002/anie.200462724https://infoscience.epfl.ch/handle/20.500.14299/225911WOS:0002288718000306781By introducing a photolabile group in the Watson-Crick base-pairing site of a guanosine residue, a bistable 20-base RNA sequence was forced into a less stable conformation. A single laser pulse released the native sequence, and the subsequent refolding equilibration was monitored with time-resolved NMR spectroscopy. This permitted a quant. description of the refolding process. [on SciFinder (R)]Kinetics of photoinduced RNA refolding by real-time NMR spectroscopytext::journal::journal article::research article