Crettaz, RogerWaser, JeromeBessard, Yves2007-12-172007-12-172007-12-17200110.1021/op010012khttps://infoscience.epfl.ch/handle/20.500.14299/157862,3-Dichloropyridines undergo a mono- or a dicarbonylation in the presence of carbon monoxide, an alc., and a palladium catalyst, affording selectively either alkyl 3-chloropyridine-2-carboxylates or dialkyl pyridine-2,3-dicarboxylates in good yields, depending on the reaction conditions. For instance, the process could be scaled up for the monoalkoxycarbonylation of 2,3-dichloro-5-(trifluoromethyl)pyridine, affording in high yield and selectivity the corresponding 3-chloro-5-(trifluoromethyl)pyridine-2-carboxylate. [on SciFinder (R)]Alkoxycarbonylation (regioselective; process for large-scale regioselective palladium-catalyzed alkoxycarbonylation of chloropyridines)process regioselective alkoxycarbonylation chloropyridine palladium catalyst; pyridinecarboxylate large scale prepntext::journal::journal article::research article