Rao, R.Mitic, J.Serov, A.Leitgeb, R. A.Lasser, T.2008-02-252008-02-252008-02-25200710.1016/j.optcom.2006.10.044https://infoscience.epfl.ch/handle/20.500.14299/19106WOS:000244488900027The solid immersion lens (SIL) as a tool for increasing the field confinement as well as providing optimal performance by aberration compensation in a confocal fluorescence correlation spectroscopy (FCS) system is illustrated here. Using Zernike polynomials we show that aberration compensation and the resultant pre-shaping of the incident wavefront enables near diffraction-limited performance. This is explained based on vectorial computations for high apertures in the Debye approximation. The obtained axial resolution parameters are compared with the obtained diffusion times in a SIL-FCS experiment for measurements in solutions done at the single molecule level.Fluorescence correlation spectroscopySolid immersion lensAberration compensationtext::journal::journal article::research article