Jain, ManishZellweger, MatthieuWagnieres, GeorgesVan Den Bergh, HubertCook, StephaneGiraud, Marie-Noelle2017-05-012017-05-012017-05-01201710.1111/1755-5922.12238https://infoscience.epfl.ch/handle/20.500.14299/136770WOS:000397576100003Acute coronary syndrome is a life-threatening condition of utmost clinical importance, which, despite recent progress in the field, is still associated with high morbidity and mortality. Acute coronary syndrome results from a rupture or erosion of vulnerable atherosclerotic plaque with secondary platelet activation and thrombus formation, which leads to partial or complete luminal obstruction of a coronary artery. During the last decade, scientific evidence demonstrated that when an acute coronary event occurs, several nonculprit plaques are in a vulnerable state. Among the promising approaches, several investigations provided evidence of photodynamic therapy (PDT)-induced stabilization and regression of atherosclerotic plaque. Significant development of PDT strategies improved its therapeutic outcome. This review addresses PDT's pertinence and major problems/challenges toward its translation to a clinical reality.AtherosclerosisLaserPhotodynamic therapyPhotosensitizersRestenosisTheranostictext::journal::journal article::review article