Sun, YuDemagny, Hadrien Charles EdouardSchoonjans, Kristina2021-05-182021-05-182021-05-182021-04-2010.1016/j.bbadis.2021.166145https://infoscience.epfl.ch/handle/20.500.14299/178082Nuclear receptors play pleiotropic roles in cell differentiation, development, proliferation, and metabolic processes to govern liver physiology and pathology. The nuclear receptor, liver receptor homolog-1 (LRH-1, NR5A2), originally identified in the liver as a regulator of bile acid and cholesterol homeostasis, was recently recognized to coordinate a multitude of other hepatic metabolic processes, including glucose and lipid processing, methyl group sensing, and cellular stress responses. In this review, we summarize the physiological and pathophysiological functions of LRH-1 in the liver, as well as the molecular mechanisms underlying these processes. This review also focuses on the recent advances highlighting LRH-1 as an attractive target for liver-associated diseases, such as non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC).NR5A2HepatocytesNAFLDNASHHCCtext::journal::journal article::research article