Amino or Thiol Linker Building Block for the Synthesis of Amino- or Thiol-functionalized nucleic acids and Methods of Making and Use Thereof

Weiss, Patrick A.Weiss, Violette Y.Pitsch, Stefan2007-03-072007-03-072007-03-072006https://infoscience.epfl.ch/handle/20.500.14299/3529An amino or thiol linker building block for the synthesis of amino or thiol functionalized amino acids and generally of the following structure: Formula XII is provided. Such building block may be introduced in the 5' end position of an amino acid under standard coupling conditions. Such building block allows inline coupling control, "trityl-on" purification, and solid support functionalization/derivatization. Such building block is a stable, solid compound and can therefore be easily handled. With the building block of the present invention, deprotection may be carried out under standard detritylation conditions.Amino or Thiol Linker Building Block for the Synthesis of Amino- or Thiol-functionalized nucleic acids and Methods of Making and Use ThereofpatentUS7772439EP1809647JP2008517950EP1809647WO2006047628US2006167240CA2584799WO200604762836228444