Corti, MattiaZingaro, AlbertoDede', LucaQuarteroni, Alfio Maria2022-11-072022-11-072022-11-072022-11-0110.1016/j.compbiomed.2022.106143https://infoscience.epfl.ch/handle/20.500.14299/191909WOS:000869635300001We analyse the haemodynamics of the left atrium, highlighting differences between healthy individuals and patients affected by atrial fibrillation. The computational study is based on patient-specific geometries of the left atria to simulate blood flow dynamics. We design a novel procedure to compute the boundary data for the 3D haemodynamic simulations, which are particularly useful in absence of data from clinical measurements. With this aim, we introduce a parametric definition of atrial displacement, and we use a closed-loop lumped parameter model of the whole cardiovascular circulation conveniently tuned on the basis of the patient's characteristics. We evaluate several fluid dynamics indicators for atrial haemodynamics, validating our numerical results in terms of clinical measurements; we investigate the impact of geometric and clinical characteristics on the risk of thrombosis. To highlight the correlation of thrombus formation with atrial fibrillation, according to medical evidence, we propose a novel indicator: age stasis. It arises from the combination of Eulerian and Lagrangian quantities. This indicator identifies regions where slow flow cannot properly rinse the chamber, accumulating stale blood particles, and creating optimal conditions for clots formation.BiologyComputer Science, Interdisciplinary ApplicationsEngineering, BiomedicalMathematical & Computational BiologyLife Sciences & Biomedicine - Other TopicsComputer ScienceEngineeringcomputational fluid dynamicscardiac modellingleft atrium haemodynamicsatrial fibrillationleft atrial appendage4d flow mricardiovascular-systemadult patientsblood stasisvelocityechocardiographyassociationbifurcationmechanismspressurestext::journal::journal article::research article