Bello, ClaudiaDal Bello, GiovannaCea, MicheleNahimana, AimableAubry, DominiqueGaruti, AnnaMotta, GiuliaMoran, EvaFruscione, FlorianaPronzato, PaoloGrossi, FrancescoPatrone, FrancoBallestrero, AlbertoDupuis, MarcSordat, BernardZimmermann, KasparLoretan, JacquelineWartmann, MarkusDuchosal, Michel A.Nencioni, AlessioVogel, Pierre2012-06-122012-06-122012-06-12201110.1016/j.bmc.2011.07.053https://infoscience.epfl.ch/handle/20.500.14299/81563WOS:000297860100044New derivatives of 1,4-dideoxy-1,4-imino-D-ribitol have been prepared and evaluated for their cytotoxicity on solid and haematological malignancies. 1,4-Dideoxy-5-O-[(9Z)-octadec-9-en-1-yl]-1,4-imino-Dribitol (13, IC50 similar to 2 mu M) and its C-18-analogues (IC50 < 10 mu M) are cytotoxic toward SKBR3 (breast cancer) cells. 13 also inhibits (IC50 similar to 8 mu M) growth of JURKAT cells. (C) 2011 Published by Elsevier Ltd.Breast cancerIminoalditolsJURKAT cellsOleyl derivativeLysosomal Storage DisordersEt-18-Och3 EdelfosineDrug DiscoveryCancer-CellsImino SugarsTumor-CellsJaspine-BDerivativesInhibitorsBiosynthesistext::journal::journal article::research article