Gualtierotti, Jean-BaptisteSchumacher, XavierWang, QianZhu, Jieping2013-05-142013-05-142013-05-14201310.1055/s-0032-1316908https://infoscience.epfl.ch/handle/20.500.14299/92217WOS:000319406800012Oxidative three-component reaction of aldehydes, amines, and TMSCN in a biphasic solvent system (toluene/H2O) containing Oxone, tetra-n-butylammonium bromide (TBAB) and sodium bicarbonate afforded α-iminonitriles in good to excellent yields. This oxidative Strecker reaction was applicable to a wide range of aldehydes and amines, aromatic or aliphatic, of different electronic and steric properties. Substituted 1-aza-2-cyano-1,3-dienes were also accessible using α,β-unsaturated aldehydes as inputs.α-iminonitrileOxoneα-aminonitrileoxidative threecomponent Strecker reactionmulticomponent reactiontext::journal::journal article::research article