Pisella, GuillaumeGagnebin, AlecWaser, Jerome2020-07-302020-07-302020-07-302020-03-1810.1002/chem.202001317https://infoscience.epfl.ch/handle/20.500.14299/170451WOS:000548412900001Multicomponent reactions provide efficient means to access molecular complexity. Herein, we report a copper-catalyzed three-component reaction of diazo compounds, alcohols and ethynyl benziodoxole (EBX) reagents for the synthesis of propargyl ethers. Extensive variations of the three partners of the reaction is possible, leading to highly functionalized and structurally diverse products under mild conditions. Alkynylation of a copper ylide intermediate is postulated as key step for this transformation.Chemistry, MultidisciplinaryChemistrycarbenescopper catalysishypervalent iodine reagentsmulti-component reactions (mcr)synthetic methodscatalyzed oxy-alkynylationdiazo-compoundsmulticomponent reactionsdiazocarbonyl compoundscooperative catalysisoxonium ylidescopperalcoholsconstructioncondensationtext::journal::journal article::research article