Targeting molecular recognition: exploring the dual role of functional pseudoprolines in the design of SH3 ligands

Tuchscherer, GabrieleGrell, DanielTatsu, YoshiroDurieux, PatriciaFernandez-Carneado, JimenaHengst, BeatriceKardinal, ChristianFeller, Stephan2006-02-092006-02-092006-02-09200110.1002/1521-3773(20010803)40:15<2844::AID-ANIE2844>3.0.CO;2-Fhttps://infoscience.epfl.ch/handle/20.500.14299/222275Pseudoproline-contg. peptide MeCO-Pro-Pro-Pro-Xaa-Pro-Val-Xaa-Pro-Pro-Pro-Pro-OH [Xaa = Ser(yProPh,H) = 2(S)-phenyloxazolidinyl-4-carboxylate] was synthesized and its conformation was examd. by CD spectroscopy. Its inhibition of the Grb2-SH3 domain was tested. [on SciFinder (R)]Targeting molecular recognition: exploring the dual role of functional pseudoprolines in the design of SH3 ligandstext::journal::journal article::research article