Bonnaterre, FlorenceBois-Choussy, MicheleZhu, Jieping2010-11-252010-11-252010-11-25200610.1021/ol061755zhttps://infoscience.epfl.ch/handle/20.500.14299/58457A two-step sequence involving an Ugi four-component reaction (Ugi-4CR) and a palladium-catalyzed intramol. amidation of aryl iodide has been developed for rapid access to functionalized oxindoles, e.g., I. Microwave heating was used to accelerate and to improve the efficiency of the intramol. Buchwald-Hartwig reaction. [on SciFinder (R)]Amidation (Buchwald-Hartwigintramol.; prepn. of oxindoles via Ugi four-component reaction of amine with iodobenzaldehydecarboxylic acid and isonitrile followed by copper-catalyzed Ullmann or microwave-assisted Buchwald-Hartwig amidation); Addition reaction (Ugi; prepn. of oxindoles via Ugi four-component reaction of amine with iodobenzaldehydecarboxylic acid and isonitrile followed by copper-catalyzed Ullmann or microwave-assisted Buchwald-Hartwig amidation); Coupling reaction catalysts (Ullmann; prepn. of oxindoles via Ugi four-component reaction of amine with iodobenzaldehydecarboxylic acid and isonitrile followed by copper-catalyzed Ullmann or microwave-assisted Buchwald-Hartwig amidation); Amides Role: RCT (Reactant)SPN (Synthetic preparation)PREP (Preparation)RACT (Reactant or reagent) (bisamides; prepn. of oxindoles via Ugi four-component reaction of amine with iodobenzaldehydecarboxylic acid and isonitrile followed by copper-catalyzed Ullmann or microwave-assisted Buchwald-Hartwig amidation); Aldehydes Role: RCT (Reactant)RACT (Reactant or reagent) (haloarom.iodo; prepn. of oxindoles via Ugi four-component reaction of amine with iodobenzaldehydecarboxylic acid and isonitrile followed by copper-catalyzed Ullmann or microwave-assisted Buchwald-Hartwig amidation); Aromatic hydrocarbons Role: RCT (Reactant)SPN (Synthetic preparation)PREP (Preparation)RACT (Reactant or reagent) (halo; prepn. of oxindoles via Ugi four-component reaction of amine with iodobenzaldehydecarboxylic acid and isonitrile followed by copper-catalyzed Ullmann or microwave-assisted Buchwald-Hartwig amidation); Microwave (irradn.; prepn. of oxindoles via Ugi four-component reaction of amine with iodobenzaldehydecarboxylic acid and isonitrile followed by copper-catalyzed Ullmann or microwave-assisted Buchwald-Hartwig amidation); Amidation catalysts; Ullmann reaction (prepn. of oxindoles via Ugi four-component reaction of amine with iodobenzaldehydecarboxylic acid and isonitrile followed by copper-catalyzed Ullmann or microwave-assisted Buchwald-Hartwig amidation); Amines; Carboxylic acids; Isocyanides Role: RCT (Reactant)RACT (Reactant or reagent) (prepn. of oxindoles via Ugi four-component reaction of amine with iodobenzaldehydecarboxylic acid and isonitrile followed by copper-catalyzed Ullmann or microwave-assisted Buchwald-Hartwig amidation)amine iodobenzaldehyde carboxylic acid isonitrile Ugi multicomponent addn palladium; iodophenylacetamide acylamino prepn intramol Ullmann coupling copper; acylamino iodophenylacetamide prepn intramol Buchwald Hartwig amidation microwave irradn; oxindole deriv prepn; indole oxo deriv prepn; copper intramol Ullmann coupling; palladium Ugi four component addn catalyst; Buchwald Hartwig amidation palladium catalyst; microwave irradn intramol Buchwald Hartwig amidation mediatorRapid access to oxindoles by the combined use of an Ugi four-component reaction and a microwave-assisted intramolecular Buchwald-Hartwig amidation reactiontext::journal::journal article::research article