Stella, SimoneRegazzonit, FrancescoVergara, ChristianDede, LucaQuarteroni, Alfio2022-09-262022-09-262022-09-262022-07-2510.1142/S021820252250035Xhttps://infoscience.epfl.ch/handle/20.500.14299/190967WOS:000849624100001We present a new model of human cardiac electromechanics for the left ventricle where electrophysiology is described by a Reaction-Eikonal model and which enables an off-line resolution of the reaction model, thus entailing a big saving of computational time. Subcellular dynamics is coupled with a model of tissue mechanics, which is in turn coupled with a Windkessel model for blood circulation. Our numerical results show that the proposed model is able to provide a physiological response to changes in certain variables (end-diastolic volume, total peripheral resistance, contractility). We also show that our model is able to reproduce with high accuracy and with a considerably lower computational time the results that we would obtain if the monodomain model should be used in place of the Eikonal model.Mathematics, AppliedMathematicscardiac electromechanicseikonal modelpv loopsnumerical simulationshearttissuecontractionmonodomainexcitationalgorithmpropagationmyocardiumactivationgenerationtext::journal::journal article::research article